the differential expression of microrna-143,145 in endometriosis
نویسندگان
چکیده
background: objective: to understand the changes of mirnas in endometriosis. materials and methods: with real-time rt-pcr, we investigated the mir-143 and mir-145 expression in eutopic (eu, n=2) and ectopic endometrium (ec, n=11) (from women with endometriosis) (as well as eu+ec, n=11), along with the normal endometrium (en, n=22) (from women without endometriosis, but with leiomyoma). results: we did not find that the expression of mir-143 and/or mir-145 in en or ec changed with menstrual cycle. but our results showed the mir-143 was up-regulated in ec (p=0.000) compared to en. the mir-143 was also up-regulated in eu, but the difference did not reach statistically significance (p=0.053). compared to eu, the expression of mir-143 in ec was up-regulated (p=0.016). mir-145 had the similar characteristic to mir-143. the mir-145 was up-regulated in both eu (p=0.004) and ec (p=0.000) in compared to en group. when compared with eu, the mir-145 in ec was up-regulated (p=0.008). conclusion: in conclusion, the mir-143 and mir-145 may play a certain role in the development and progression of endometriosis. recent studies showed that inappropriate expression of micrornas (mirnas) is strongly associated with tumor-related processes in humans (2-9,11-17).
منابع مشابه
The differential expression of microRNA-143,145 in endometriosis
BACKGROUND Recent studies showed that inappropriate expression of microRNAs (miRNAs) is strongly associated with tumor-related processes in humans (2-9,11-17). OBJECTIVE To understand the changes of miRNAs in endometriosis. MATERIALS AND METHODS With real-time RT-PCR, we investigated the miR-143 and miR-145 expression in eutopic (EU, n=2) and ectopic endometrium (EC, n=11) (from women with ...
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Objective(s): The purpose of this study was to conduct a meta-analysis on human microRNAs (miRNAs) expression data of endometriosis tissue profiles versus those of normal controls and to identify novel putative diagnostic markers. Materials andMethods: PubMed, Embase, Web of Science, Ovid Medline were used to search for endometriosis miRNA expression profiling studies of endometriosis. The miRN...
متن کاملsystematic enrichment analysis of microrna expression profiling studies in endometriosis
objective(s): the purpose of this study was to conduct a meta-analysis on human micrornas (mirnas) expression data of endometriosis tissue profiles versus those of normal controls and to identify novel putative diagnostic markers. materials andmethods: pubmed, embase, web of science, ovid medline were used to search for endometriosis mirna expression profiling studies of endometriosis. the mirn...
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عنوان ژورنال:
international journal of reproductive biomedicineجلد ۱۲، شماره ۸، صفحات ۵۵۵-۰
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